ESTIMATE is a tool for predicting tumor purity, and the presence of infiltrating stromal/immune cells in tumor tissues using gene expression data. Its algorithm is based on single sample Gene Set Enrichment Analysis, and generates three scores:
- stromal score (that captures the presence of stroma in tumor tissue)
- immune score (that represents the infiltration of immune cells in tumor tissue)
- estimate score (that infers tumor purity)
Click
here for the software's official
MDACC landing
page, which provides a link to the ESTIMATE scores for all
TCGA tumor types.
Click
here for the R-Forge project summary page.